NEW BIOMATERIALS/TISSUE ENGINEERING: “Thermally Treated FeCrAl Alloy as Potential Biomaterial”

Fig.1, a-l. Pro-Odontoblast Cultured Cells Growing on the Surface of Oxidized FeCrAl Alloy. LSM (a-f)+SEM (h-j) Imaging

 

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RADIOLOGY/RADIOTHERAPY: “Dynamics of Large-Scale Nuclear and Nucleolar Changes Under γ-Irradiation Induced Ribosomal DNA Chromatin Damage”

Fig. 2. Histone H2B-GFP (Green) Permanently Transfected He-La Culture Cells. Anti-Fibrillarin (Red) Immunostaining. Mitotic Catastrophe: Nuclear Fragmentation (Nucleus in Lower Left Corner) After 30 Gy γ-Irradiation and 72 Hour of Post-Radiation Image Acquisition; LSM+“Chimera” Software Generated 3D Model

 

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CELL BIOLOGY/CYTOGENETICS: “Intra-nuclear Structure-Functional 3D/4D Interplay Between Ribosomal RNA Genes and Satellite DNA Sequences in Regard to Structures They Generate”

Fig. 3, a-b. 3D LSM Imaging: RAW264.7 Cell Line; FISH+DAPI double labeling of centromere (red) and telomere (green). 

 

CANCER CELL BIOLOGY/CANCER MORPHO-DIAGNOSTICS: “Cancer Cell Nucleolus as Reliable Differential Diagnostic and Prognostic Criterion by Assessing Tissue Form, Malignancy Grade, Progression Potential in Human Benign and Malignant Tumors”

Fig. 4. Human Mammary Gland In Situ Carcinoma. Stage of Penetration of Basal Membrane by Dark Cells (Center of Image) and Their Protrusion into Connective Tissue Stroma. Paraffin Embedding and H&E Staining

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NEW DRUG RESEARCH AND DEVELOPMENT:  “Adamantan Fragment Containing Molecules as Potential Anticancer Drugs Unraveled by Correlative  4D Light and 3D Electron Microscopy”

Fig. 5. Nucleus (Green) of Histone H2B-GFP permanently Transfected He-La Cells. Anti-UBTF Immunostaining. 3D LSM Imaging. 12 Hours of Action of Anti-Cancer Drug CisPt. Note enlarged Fibrillar Centers

 

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TISSUE ENGINEERING/NEW BIOMASTERIALS: “Lab-Grown Tissue Bio-Mimetics Using Nature Inspired Leucine-Based Pseudo Proteins (LPPs) 3D Printed Scaffolds” 

 

Fig.6, a-f. 2D Culture of Mouse Dermal Fibroblasts Growing on the Surface of Leucine-Based Pseudo Protein Film. SEM Imaging